[HTML][HTML] Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5
H Nishitoh, H Ichijo, M Kimura, T Matsumoto… - Journal of biological …, 1996 - ASBMB
Growth/differentiation factor-5 (GDF-5) is a member of the bone morphogenetic protein
(BMP) family, which plays an important role in bone development in vivo. Mutations in the
GDF-5 gene result in brachypodism in mice and Hunter-Thompson type chondrodysplasia in
human. BMPs transduce their effects through binding to two different types of
serine/threonine kinase receptors, type I and type II. However, binding abilities appear to be
different among the members of the BMP family. BMP-4 binds to two different type I …
(BMP) family, which plays an important role in bone development in vivo. Mutations in the
GDF-5 gene result in brachypodism in mice and Hunter-Thompson type chondrodysplasia in
human. BMPs transduce their effects through binding to two different types of
serine/threonine kinase receptors, type I and type II. However, binding abilities appear to be
different among the members of the BMP family. BMP-4 binds to two different type I …