[HTML][HTML] Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway

E Haÿ, J Lemonnier, O Fromigué, PJ Marie - Journal of Biological Chemistry, 2001 - ASBMB
Bone morphogenetic protein-2 (BMP-2), a member of the transforming growth factor-β (TGF-
β) family, regulates osteoblast differentiation and bone formation. Here we show a novel
function of BMP-2 in human osteoblasts and identify a signaling pathway involved in this
function. BMP-2 promotes apoptosis in primary human calvaria osteoblasts and in
immortalized human neonatal calvaria osteoblasts, as shown by terminal deoxynucleotidyl
transferase-mediated nick end labeling analysis. In contrast, TGF-β2 inhibits apoptosis in …