[CITATION][C] Chronic neutrophilic leukaemia associated with polycythemia vera: pathogenetic implications and therapeutic approach
P Foa, A Iurlo, G Saglio, A Guerrasio… - British journal of …, 1991 - Wiley Online Library
P Foa, A Iurlo, G Saglio, A Guerrasio, F Capsoni, AT Maiolo
British journal of haematology, 1991•Wiley Online LibraryChronic neutrophilic leukaemia (CNL) is a rare disease characterized by persistent
leucocytosis consisting almost entirely of mature neutrophils, increased leucocyte alkaline
phosphatase (LAP) score, elevated serum B12 and uric acid levels, bone marrow
granulocytic hyperplasia and absence of the Philadelphia chromosome (Ph')(Cervantes et
al. 1988). Owing to the difficulty in distinguishing this picture from leukaemoid reactions, the
recognition of CNL as a real entity has sometimes been questioned and there is controversy …
leucocytosis consisting almost entirely of mature neutrophils, increased leucocyte alkaline
phosphatase (LAP) score, elevated serum B12 and uric acid levels, bone marrow
granulocytic hyperplasia and absence of the Philadelphia chromosome (Ph')(Cervantes et
al. 1988). Owing to the difficulty in distinguishing this picture from leukaemoid reactions, the
recognition of CNL as a real entity has sometimes been questioned and there is controversy …
Chronic neutrophilic leukaemia (CNL) is a rare disease characterized by persistent leucocytosis consisting almost entirely of mature neutrophils, increased leucocyte alkaline phosphatase (LAP) score, elevated serum B12 and uric acid levels, bone marrow granulocytic hyperplasia and absence of the Philadelphia chromosome (Ph’)(Cervantes et al. 1988). Owing to the difficulty in distinguishing this picture from leukaemoid reactions, the recognition of CNL as a real entity has sometimes been questioned and there is controversy about the myeloproliferative nature of this disease (Lugassi &
Wiley Online Library