[HTML][HTML] TWEAK mediates signal transduction and differentiation of RAW264. 7 cells in the absence of Fn14/TweakR: evidence for a second TWEAK receptor
TC Polek, M Talpaz, BG Darnay… - Journal of Biological …, 2003 - ASBMB
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) is a member of the tumor
necrosis factor family that is implicated in apoptosis, proliferation, migration, and
inflammation. We describe our findings showing that TWEAK mediated the differentiation of
RAW264. 7 (RAW) monocyte/macrophage cells into multinuclear, functional osteoclasts. The
effect of TWEAK was direct and not mediated by the receptor activator of nuclear factor-κB
(NF-κB) ligand (RANKL) as shown by the use of TWEAK-or RANKL-neutralizing antibodies …
necrosis factor family that is implicated in apoptosis, proliferation, migration, and
inflammation. We describe our findings showing that TWEAK mediated the differentiation of
RAW264. 7 (RAW) monocyte/macrophage cells into multinuclear, functional osteoclasts. The
effect of TWEAK was direct and not mediated by the receptor activator of nuclear factor-κB
(NF-κB) ligand (RANKL) as shown by the use of TWEAK-or RANKL-neutralizing antibodies …