TWEAK, a member of the TNF superfamily, is a multifunctional cytokine that binds the TweakR/Fn14 receptor
SR Wiley, JA Winkles - Cytokine & growth factor reviews, 2003 - Elsevier
The cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) was initially
described as a member of the tumor necrosis factor (TNF) superfamily in 1997. TWEAK is a
cell surface-associated type II transmembrane protein, but a smaller, biologically active form
can also be shed into the extracellular milieu. There is one receptor currently known to bind
TWEAK with physiological affinity, and it is a type I transmembrane protein that is referred to
in the literature as either TWEAK receptor (TweakR) or fibroblast growth factor-inducible 14 …
described as a member of the tumor necrosis factor (TNF) superfamily in 1997. TWEAK is a
cell surface-associated type II transmembrane protein, but a smaller, biologically active form
can also be shed into the extracellular milieu. There is one receptor currently known to bind
TWEAK with physiological affinity, and it is a type I transmembrane protein that is referred to
in the literature as either TWEAK receptor (TweakR) or fibroblast growth factor-inducible 14 …