Effect of thiazolidinediones on body weight in patients with diabetes mellitus

V Fonseca - The American journal of medicine, 2003 - Elsevier
Treatment of diabetes mellitus with medications, including insulin, sulfonylureas, and
thiazolidinediones (TZDs), often leads to weight gain through a variety of mechanisms.
Weight gain can have adverse consequences for patients with type 2 diabetes, many of
whom are overweight or obese, because obesity is linked to insulin resistance and other
medical consequences such as cardiovascular disease. TZDs improve glycemic control and
insulin sensitivity in patients with type 2 diabetes, despite their potential to cause weight …