Antigen processing and presentation by intestinal epithelial cells–polarity and complexity
RM Hershberg, LF Mayer - Immunology today, 2000 - cell.com
RM Hershberg, LF Mayer
Immunology today, 2000•cell.comThe mechanisms by which gut-associated lymphoid tissue (GALT) maintains a balance
between oral tolerance and active immune response in the face of exposure to high antigen
concentrations remains a central question in mucosal immunity. Here, Robert Hershberg
and colleagues discuss the evidence that human intestinal epithelial cells function as
antigen-presenting cells (APCs) capable of regulating T-cell responses in the intestinal
mucosa
between oral tolerance and active immune response in the face of exposure to high antigen
concentrations remains a central question in mucosal immunity. Here, Robert Hershberg
and colleagues discuss the evidence that human intestinal epithelial cells function as
antigen-presenting cells (APCs) capable of regulating T-cell responses in the intestinal
mucosa
Abstract
The mechanisms by which gut-associated lymphoid tissue (GALT) maintains a balance between oral tolerance and active immune response in the face of exposure to high antigen concentrations remains a central question in mucosal immunity. Here, Robert Hershberg and colleagues discuss the evidence that human intestinal epithelial cells function as antigen-presenting cells (APCs) capable of regulating T-cell responses in the intestinal mucosa
cell.com