[HTML][HTML] The extra domain A of fibronectin activates Toll-like receptor 4
Y Okamura, M Watari, ES Jerud, DW Young… - Journal of Biological …, 2001 - ASBMB
Cellular fibronectin, which contains an alternatively spliced exon encoding type III repeat
extra domain A (EDA), is produced in response to tissue injury. Fragments of fibronectin
have been implicated in physiological and pathological processes, especially tissue
remodeling associated with inflammation. Because EDA-containing fibronectin fragments
produce cellular responses similar to those provoked by bacterial lipopolysaccharide (LPS),
we examined the ability of recombinant EDA to activate Toll-like receptor 4 (TLR4), the …
extra domain A (EDA), is produced in response to tissue injury. Fragments of fibronectin
have been implicated in physiological and pathological processes, especially tissue
remodeling associated with inflammation. Because EDA-containing fibronectin fragments
produce cellular responses similar to those provoked by bacterial lipopolysaccharide (LPS),
we examined the ability of recombinant EDA to activate Toll-like receptor 4 (TLR4), the …