[HTML][HTML] Selective uptake of low density lipoprotein-cholesteryl ester is enhanced by inducible apolipoprotein E expression in cultured mouse adrenocortical cells
S Swarnakar, ME Reyland, J Deng, S Azhar… - Journal of Biological …, 1998 - ASBMB
Apolipoprotein (apo) E is expressed at high levels by steroidogenic cells of the adrenal
gland, ovary, and testis. The cell surface location of apoE in adrenocortical cells suggests
that apoE may facilitate the uptake of lipoprotein cholesterol by either the endocytic or the
selective uptake pathways, or both. To examine these possibilities, the human apoE gene
was expressed in murine Y1 adrenocortical cells under control of an inducible tetracycline-
regulated promoter. The results show that induction of apoE yielded a 2–2.5-fold increase in …
gland, ovary, and testis. The cell surface location of apoE in adrenocortical cells suggests
that apoE may facilitate the uptake of lipoprotein cholesterol by either the endocytic or the
selective uptake pathways, or both. To examine these possibilities, the human apoE gene
was expressed in murine Y1 adrenocortical cells under control of an inducible tetracycline-
regulated promoter. The results show that induction of apoE yielded a 2–2.5-fold increase in …