[HTML][HTML] ApoB-containing lipoproteins in apoE-deficient mice are not metabolized by the class B scavenger receptor BI
NR Webb, MC de Beer, FC de Beer… - Journal of lipid …, 2004 - ASBMB
The scavenger receptor class B type I (SR-BI) recognizes a broad variety of lipoprotein
ligands, including HDL, LDL, and oxidized LDL. In this study, we investigated whether SR-BI
plays a role in the metabolism of cholesterol-rich lipoprotein remnants that accumulate in
apolipoprotein E (apoE)−/− mice. These particles have an unusual apolipoprotein
composition compared with conventional VLDL and LDL, containing mostly apoB-48 as well
as substantial amounts of apoA-I and apoA-IV. To study SR-BI activity in vivo, the receptor …
ligands, including HDL, LDL, and oxidized LDL. In this study, we investigated whether SR-BI
plays a role in the metabolism of cholesterol-rich lipoprotein remnants that accumulate in
apolipoprotein E (apoE)−/− mice. These particles have an unusual apolipoprotein
composition compared with conventional VLDL and LDL, containing mostly apoB-48 as well
as substantial amounts of apoA-I and apoA-IV. To study SR-BI activity in vivo, the receptor …