Two trioleoyl glycerol hydrolases, one of lysosomal origin as determined by a high
correlation with the lysosomal marker enzyme, N-acetyl-β-glucosaminidase, and one having
the characteristics of lipoprotein lipase, were measured at varying stages of lesion
development in the aortas of cholesterol-fed rabbits. Both lipases were greatly enhanced in
atheromatous aortas and were linearly related to lesion severity as measured by total aortic
cholesterol. Lipoprotein lipase activities of myocardium and of plasma of cholesterol-fed …