[HTML][HTML] Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux

Y Ji, B Jian, N Wang, Y Sun, M de la Llera Moya… - Journal of Biological …, 1997 - ASBMB
Scavenger receptor BI (SR-BI) binds high density lipoproteins (HDL) with high affinity and
mediates the selective uptake of HDL cholesteryl ester. We examined the potential role of
SR-BI in mediating cellular cholesterol efflux. In Chinese hamster ovary cells stably
transfected with murine SR-BI, overexpression of SR-BI resulted in a 3–4-fold stimulation of
initial cholesterol efflux rates. Efflux rates correlated with SR-BI expression in cells and HDL
concentration in the medium. When incubated with synthetic cholesterol-free HDL, SR-BI …