Regulation of the mevalonate pathway

JL Goldstein, MS Brown - Nature, 1990 - nature.com
JL Goldstein, MS Brown
Nature, 1990nature.com
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions,
ranging from cholesterol synthesis to growth control. Several mechanisms for feedback
regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate
biosynthesis ensure the production of sufficient mevalonate for several end-products.
Manipulation of this regulatory system could be useful in treating certain forms of cancer as
well as heart disease.
Abstract
The mevalonate pathway produces isoprenoids that are vital for diverse cellular functions, ranging from cholesterol synthesis to growth control. Several mechanisms for feedback regulation of low-density-lipoprotein receptors and of two enzymes involved in mevalonate biosynthesis ensure the production of sufficient mevalonate for several end-products. Manipulation of this regulatory system could be useful in treating certain forms of cancer as well as heart disease.
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