[HTML][HTML] Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density …
N Herijgers, MPJ de Winther, M Van Eck… - Journal of Lipid …, 2000 - ASBMB
Scavenger receptors, which include various classes, play an important role in atherogenesis
by mediating the unrestricted uptake of modified lipoproteins, resulting in the massive
accumulation of cholesteryl esters. Because macrophage-derived foam cells are considered
to be an important feature in early atherogenesis, we investigated the role of scavenger
receptor class A (SR-A) overexpression, especially on macrophages in lipoprotein
metabolism and atherosclerosis. Bone marrow from human SR-A (MSR1)-overexpressing …
by mediating the unrestricted uptake of modified lipoproteins, resulting in the massive
accumulation of cholesteryl esters. Because macrophage-derived foam cells are considered
to be an important feature in early atherogenesis, we investigated the role of scavenger
receptor class A (SR-A) overexpression, especially on macrophages in lipoprotein
metabolism and atherosclerosis. Bone marrow from human SR-A (MSR1)-overexpressing …