[HTML][HTML] Macrophage-specific expression of class A scavenger receptors in LDL receptor−/− mice decreases atherosclerosis and changes spleen morphology
SC Whitman, DL Rateri, SJ Szilvassy, JA Cornicelli… - Journal of lipid …, 2002 - ASBMB
Class A scavenger receptors (SR-A) have been implicated in the atherogenic process,
although there have been conflicting reports as to their specific effect on the development of
lesions. In part, this discord may arise because of the variable contribution of SR-A in the
several cell types known to express this protein. To determine the effects of macrophage-
specific SR-A expression in the atherogenic process, transgenic mice were created using
the chicken lysozyme (lyso) promoter to drive expression of bovine SR-A (bSR-A). To …
although there have been conflicting reports as to their specific effect on the development of
lesions. In part, this discord may arise because of the variable contribution of SR-A in the
several cell types known to express this protein. To determine the effects of macrophage-
specific SR-A expression in the atherogenic process, transgenic mice were created using
the chicken lysozyme (lyso) promoter to drive expression of bovine SR-A (bSR-A). To …