[HTML][HTML] Ceramide in lipid particles enhances heparan sulfate proteoglycan and low density lipoprotein receptor-related protein-mediated uptake by macrophages
S Morita, M Kawabe, A Sakurai, K Okuhira… - Journal of Biological …, 2004 - ASBMB
Arterial wall sphingomyelinase (SMase) has been proposed to be involved in
atherogenesis. SMase modification of lipoproteins has been shown to occur in
atherosclerotic lesions and to facilitate their uptake by macrophages and foam cell
formation. To investigate the mechanism of macrophage uptake enhanced by SMase, we
prepared lipid emulsions containing sphingomyelin (SM) or ceramide (CER) as model
particles of lipoproteins. SMase remarkably increased the uptake of SM-containing …
atherogenesis. SMase modification of lipoproteins has been shown to occur in
atherosclerotic lesions and to facilitate their uptake by macrophages and foam cell
formation. To investigate the mechanism of macrophage uptake enhanced by SMase, we
prepared lipid emulsions containing sphingomyelin (SM) or ceramide (CER) as model
particles of lipoproteins. SMase remarkably increased the uptake of SM-containing …