Early cell signaling by the cytotoxic enterotoxin of Aeromonas hydrophila in macrophages

DA Ribardo, KR Kuhl, I Boldogh, JW Peterson… - Microbial …, 2002 - Elsevier
A cytotoxic enterotoxin (Act) of Aeromonas hydrophila is an important virulence factor with
hemolytic, cytotoxic and enterotoxic activities. In this report, we demonstrated Act rapidly
mobilized calcium from intracellular stores and evoked influx of calcium from the
extracellular milieu in macrophages. A direct role of calcium in Act-induced prostaglandin
(eg PGE2) and tumor necrosis factor alpha (TNFα) production was demonstrated in
macrophages using a cell-permeable calcium chelator BAPTA-AM, which also down …