Role of 4-hydroxynonenal in stress-mediated apoptosis signaling
YC Awasthi, R Sharma, JZ Cheng, Y Yang… - Molecular aspects of …, 2003 - Elsevier
In this mini review we summarize recent studies from our laboratory, which show the
involvement of 4-hydroxynonenal (4-HNE) in cell cycle signaling. We demonstrate 4-HNE
induced apoptosis in various cell lines is accompanied with c-Jun-N-terminal kinase and
caspase-3 activation. Cells exposed to mild, transient, heat or oxidative stress acquire
capacity to exclude intracellular 4-HNE at a faster rate by inducing hGST5. 8 which
conjugate 4-HNE to GSH, and RLIP76 which mediates the ATP-dependent transport of the …
involvement of 4-hydroxynonenal (4-HNE) in cell cycle signaling. We demonstrate 4-HNE
induced apoptosis in various cell lines is accompanied with c-Jun-N-terminal kinase and
caspase-3 activation. Cells exposed to mild, transient, heat or oxidative stress acquire
capacity to exclude intracellular 4-HNE at a faster rate by inducing hGST5. 8 which
conjugate 4-HNE to GSH, and RLIP76 which mediates the ATP-dependent transport of the …