A synthetic peptide with sequence identity to the transmembrane protein GP41 of HIV-1 inhibits distinct lymphocyte activation pathways dependent on protein kinase C …
CL Ruegg, M Strand - Cellular immunology, 1991 - Elsevier
A synthetic peptide containing env amino acid (aa) sequence 581 to 597 of the
transmembrane protein gp41 of human immunodeficiency virus type 1 (HIV-1) was tested for
its effect on protein kinase C (PKC) and cytoplasmic free Ca 2+([Ca 2+] i) influx-dependent
immune functions. We have previously shown that this peptide inhibits PKC-mediated
phosphorylation and T-cell receptor-mediated [Ca 2+] i influx as well as lymphoproliferation.
In this study we demonstrate that the HIV-1 gp41 peptide aa581–597 inhibits …
transmembrane protein gp41 of human immunodeficiency virus type 1 (HIV-1) was tested for
its effect on protein kinase C (PKC) and cytoplasmic free Ca 2+([Ca 2+] i) influx-dependent
immune functions. We have previously shown that this peptide inhibits PKC-mediated
phosphorylation and T-cell receptor-mediated [Ca 2+] i influx as well as lymphoproliferation.
In this study we demonstrate that the HIV-1 gp41 peptide aa581–597 inhibits …