Mechanisms of hypertension in cardiac transplantation and the role of cyclosporine

HO Ventura, FS Malik, MR Mehra… - Current opinion in …, 1997 - journals.lww.com
HO Ventura, FS Malik, MR Mehra, DD Stapleton, FW Smart
Current opinion in cardiology, 1997journals.lww.com
The use of cyclosporine in solid organ transplantation has been shown to be associated with
the development of hypertension and nephrotoxicity. Several mechanisms, including
endothelin-mediated systemic vasoconstriction, impaired vasodilatation secondary to
reduction in nitric oxide, and altered cytosolic calcium translocation, have been proposed to
underlie cyclosporine-induced hypertension. In addition, other studies have shown
activation of the sympathetic nervous system and the renin-angiotensin system, as well as …
Abstract
The use of cyclosporine in solid organ transplantation has been shown to be associated with the development of hypertension and nephrotoxicity. Several mechanisms, including endothelin-mediated systemic vasoconstriction, impaired vasodilatation secondary to reduction in nitric oxide, and altered cytosolic calcium translocation, have been proposed to underlie cyclosporine-induced hypertension. In addition, other studies have shown activation of the sympathetic nervous system and the renin-angiotensin system, as well as abnormalities in prostaglandin metabolism, as culpable mechanisms.
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