Vascular-specific growth factors and blood vessel formation

GD Yancopoulos, S Davis, NW Gale, JS Rudge… - nature, 2000 - nature.com
GD Yancopoulos, S Davis, NW Gale, JS Rudge, SJ Wiegand, J Holash
nature, 2000nature.com
A recent explosion in newly discovered vascular growth factors has coincided with
exploitation of powerful new genetic approaches for studying vascular development. An
emerging rule is that all of these factors must be used in perfect harmony to form functional
vessels. These new findings also demand re-evaluation of therapeutic efforts aimed at
regulating blood vessel growth in ischaemia, cancer and other pathological settings.
Abstract
A recent explosion in newly discovered vascular growth factors has coincided with exploitation of powerful new genetic approaches for studying vascular development. An emerging rule is that all of these factors must be used in perfect harmony to form functional vessels. These new findings also demand re-evaluation of therapeutic efforts aimed at regulating blood vessel growth in ischaemia, cancer and other pathological settings.
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