TOR signaling

TE Harris, JC Lawrence Jr - Science's STKE, 2003 - science.org
TE Harris, JC Lawrence Jr
Science's STKE, 2003science.org
The mammalian target of rapamycin, mTOR, is a protein Ser-Thr kinase that functions as a
central element in a signaling pathway involved in the control of cell growth and
proliferation. The activity of mTOR is controlled not only by amino acids, but also by
hormones and growth factors that activate the protein kinase Akt. The signaling pathway
downstream of Akt leading to mTOR involves the protein products of the genes mutated in
tuberous sclerosis, TSC1 and TSC2, and the small guanosine triphosphatase, Rheb. In …
The mammalian target of rapamycin, mTOR, is a protein Ser-Thr kinase that functions as a central element in a signaling pathway involved in the control of cell growth and proliferation. The activity of mTOR is controlled not only by amino acids, but also by hormones and growth factors that activate the protein kinase Akt. The signaling pathway downstream of Akt leading to mTOR involves the protein products of the genes mutated in tuberous sclerosis, TSC1 and TSC2, and the small guanosine triphosphatase, Rheb. In cells, mTOR is found in a complex with two other proteins, raptor and mLST8. In this review, we describe recent progress in understanding the control of the mTOR signaling pathway and the role of mTOR-interacting proteins.
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