The redox potentials of hemoglobin and myoglobin and the shapes of their anaerobic
oxidation curves are sensitive indicators of globin alterations surrounding the active site.
This report documents concentration-dependent effects of anions on the ease of anaerobic
oxidation of representative hemoglobins and myoglobins. Hemoglobin (Hb) oxidation curves
reflect the cooperative transition from the T state of deoxyHb to the more readily oxidized R-
like conformation of metHb. Shifts in the oxidation curves for Hb A 0 as Cl− concentrations …