[HTML][HTML] Active nitric oxide produced in the red cell under hypoxic conditions by deoxyhemoglobin-mediated nitrite reduction

E Nagababu, S Ramasamy, DR Abernethy… - Journal of Biological …, 2003 - ASBMB
Recent studies have generated a great deal of interest in a possible role for red blood cells
in the transport of nitric oxide (NO) to the microcirculation and the vascular effect of this nitric
oxide in facilitating the flow of blood through the microcirculation. Many questions have,
however, been raised regarding such a mechanism. We have instead identified a
completely new mechanism to explain the role of red cells in the delivery of NO to the
microcirculation. This new mechanism results in the production of NO in the microcirculation …