[HTML][HTML] Macropinocytosis is the endocytic pathway that mediates macrophage foam cell formation with native low density lipoprotein
HS Kruth, NL Jones, W Huang, B Zhao, I Ishii… - Journal of Biological …, 2005 - ASBMB
Previously, we reported that fluid-phase endocytosis of native LDL by PMA-activated human
monocytederived macrophages converted these macrophages into cholesterol-enriched
foam cells (Kruth, HS, Huang, W., Ishii, I., and Zhang, WY (2002) J. Biol. Chem. 277, 34573-
34580). Uptake of fluid by cells can occur either by micropinocytosis within vesicles (< 0.1
μm diameter) or by macropinocytosis within vacuoles (∼ 0.5-5.0 μm) named
macropinosomes. The current investigation has identified macropinocytosis as the pathway …
monocytederived macrophages converted these macrophages into cholesterol-enriched
foam cells (Kruth, HS, Huang, W., Ishii, I., and Zhang, WY (2002) J. Biol. Chem. 277, 34573-
34580). Uptake of fluid by cells can occur either by micropinocytosis within vesicles (< 0.1
μm diameter) or by macropinocytosis within vacuoles (∼ 0.5-5.0 μm) named
macropinosomes. The current investigation has identified macropinocytosis as the pathway …