Scavenger receptors were originally defined by their ability to bind and internalize modified
lipoproteins. Macrophages express at least six structurally different cell surface receptors for
modified forms of LDL that contribute to foam cell formation in atherosclerosis. In addition to
their role in the pathology of atherosclerosis, macrophage scavenger receptors, especially
SR-A, play critical roles in innate immunity, apoptotic cell clearance, and tissue homeostasis.
In this review, we highlight recent advances in understanding the biology of macrophage …