[HTML][HTML] Sulfonylureas correct trafficking defects of ATP-sensitive potassium channels caused by mutations in the sulfonylurea receptor
F Yan, CW Lin, E Weisiger, EA Cartier… - Journal of Biological …, 2004 - ASBMB
The pancreatic ATP-sensitive potassium (K ATP) channel, a complex of four sulfonylurea
receptor 1 (SUR1) and four potassium channel Kir6. 2 subunits, regulates insulin secretion
by linking metabolic changes to β-cell membrane potential. Sulfonylureas inhibit K ATP
channel activities by binding to SUR1 and are widely used to treat type II diabetes. We report
here that sulfonylureas also function as chemical chaperones to rescue K ATP channel
trafficking defects caused by two SUR1 mutations, A116P and V187D, identified in patients …
receptor 1 (SUR1) and four potassium channel Kir6. 2 subunits, regulates insulin secretion
by linking metabolic changes to β-cell membrane potential. Sulfonylureas inhibit K ATP
channel activities by binding to SUR1 and are widely used to treat type II diabetes. We report
here that sulfonylureas also function as chemical chaperones to rescue K ATP channel
trafficking defects caused by two SUR1 mutations, A116P and V187D, identified in patients …