[HTML][HTML] Megalin antagonizes activation of the parathyroid hormone receptor
J Hilpert, A Nykjaer, C Jacobsen, G Wallukat… - Journal of Biological …, 1999 - ASBMB
Parathyroid hormone (PTH) is predominantly cleared from the circulation by glomerular
filtration and degradation in the renal proximal tubules. Here, we demonstrate that megalin,
a multifunctional endocytic receptor in the proximal tubular epithelium, mediates the uptake
and degradation of PTH. Megalin was purified from kidney membranes as the major PTH-
binding protein and shown in BIAcore analysis to specifically bind full-length PTH and amino-
terminal PTH fragments (K d 0.5 μm). Absence of the receptor in megalin knockout mice …
filtration and degradation in the renal proximal tubules. Here, we demonstrate that megalin,
a multifunctional endocytic receptor in the proximal tubular epithelium, mediates the uptake
and degradation of PTH. Megalin was purified from kidney membranes as the major PTH-
binding protein and shown in BIAcore analysis to specifically bind full-length PTH and amino-
terminal PTH fragments (K d 0.5 μm). Absence of the receptor in megalin knockout mice …