Human CLC-KB gene promoter drives the EGFP expression in the specific distal nephron segments and inner ear
K Kobayashi, S Uchida, H Okamura… - Journal of the …, 2002 - journals.lww.com
Human CLC-KB has been identified as a kidney-specific member of the CLC chloride
channel family, and mutations of the human CLC-KB gene are known to cause Bartter
syndrome type III. A precise understanding of the localization of this channel in the human
kidney is imperative to our understanding of the pathophysiology, but this has remained
unclear due to the high homology between human CLC-KB and CLC-KA, another kidney-
specific member of the same family. The high intraspecies homology also rules out an exact …
channel family, and mutations of the human CLC-KB gene are known to cause Bartter
syndrome type III. A precise understanding of the localization of this channel in the human
kidney is imperative to our understanding of the pathophysiology, but this has remained
unclear due to the high homology between human CLC-KB and CLC-KA, another kidney-
specific member of the same family. The high intraspecies homology also rules out an exact …