Assignment of the human heart tetrodotoxin-resistant voltage-gated Na+ channel α-subunit gene (SCN5A) to band 3p21
AL George, Jr, TA Varkony, HA Drabkin, J Han… - … and Genome Research, 1995 - karger.com
AL George, Jr, TA Varkony, HA Drabkin, J Han, JF Knops, WH Finley, GB Brown, DC Ward…
Cytogenetic and Genome Research, 1995•karger.comThe chromosomal location of SCN5A, the gene encoding the principal voltage-gated Na+
channel expressed in human heart, has been determined by three independent
methodologies: somatic cell hybrid mapping, chromosomal micro-dissection-polymerase
chain reaction, and fluorescence in situ hybridization. The SCN5A gene was assigned to the
short arm of chromosome 3 (band 3p21) by all three approaches. These data are further
evidence that striated muscle Na+ channel genes are dispersed in the genome.
channel expressed in human heart, has been determined by three independent
methodologies: somatic cell hybrid mapping, chromosomal micro-dissection-polymerase
chain reaction, and fluorescence in situ hybridization. The SCN5A gene was assigned to the
short arm of chromosome 3 (band 3p21) by all three approaches. These data are further
evidence that striated muscle Na+ channel genes are dispersed in the genome.
Abstract
The chromosomal location of SCN5A, the gene encoding the principal voltage-gated Na+ channel expressed in human heart, has been determined by three independent methodologies: somatic cell hybrid mapping, chromosomal micro-dissection-polymerase chain reaction, and fluorescence in situ hybridization. The SCN5A gene was assigned to the short arm of chromosome 3 (band 3p21) by all three approaches. These data are further evidence that striated muscle Na+ channel genes are dispersed in the genome.
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