[HTML][HTML] A full biological response to autoantibodies in Graves' disease requires a disulfide-bonded loop in the thyrotropin receptor N terminus homologous to a …
CR Chen, K Tanaka, GD Chazenbalk… - Journal of Biological …, 2001 - ASBMB
We observed amino acid homology between the cysteine-rich N terminus of the thyrotropin
receptor (TSHR) ectodomain and epidermal growth factor-like repeats in the laminin γ1
chain. Thyroid-stimulating autoantibodies (TSAb), the cause of Graves' disease, interact with
this region of the TSHR in a manner critically dependent on antigen conformation. We
studied the role of the cluster of four cysteine (Cys) residues in this region of the TSHR on
the functional response to TSAb in Graves' patients' sera. As a benchmark we also studied …
receptor (TSHR) ectodomain and epidermal growth factor-like repeats in the laminin γ1
chain. Thyroid-stimulating autoantibodies (TSAb), the cause of Graves' disease, interact with
this region of the TSHR in a manner critically dependent on antigen conformation. We
studied the role of the cluster of four cysteine (Cys) residues in this region of the TSHR on
the functional response to TSAb in Graves' patients' sera. As a benchmark we also studied …