T-cell selection
SC Jameson, MJ Bevan - Current opinion in immunology, 1998 - Elsevier
SC Jameson, MJ Bevan
Current opinion in immunology, 1998•ElsevierMajor histocompatibility complex (MHC) molecules in the thymus select from the repertoire
of germline receptors those that will be most useful in mounting responses to antigen in the
periphery. Recent data has shed light on the involvement of self peptides presented by the
MHC in this process, and has indicated that a requirement for the constant recognition of
'self'may be essential for T-cell longevity in the periphery.
of germline receptors those that will be most useful in mounting responses to antigen in the
periphery. Recent data has shed light on the involvement of self peptides presented by the
MHC in this process, and has indicated that a requirement for the constant recognition of
'self'may be essential for T-cell longevity in the periphery.
Major histocompatibility complex (MHC) molecules in the thymus select from the repertoire of germline receptors those that will be most useful in mounting responses to antigen in the periphery. Recent data has shed light on the involvement of self peptides presented by the MHC in this process, and has indicated that a requirement for the constant recognition of ‘self’ may be essential for T-cell longevity in the periphery.
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