It remains unclear which cells present fed antigen and whether their phenotype and/or
activation state differs between oral tolerance and priming. Furthermore, it is also
controversial whether the presentation occurs locally in the gut and/or systemically.
Clarifying these issues will be important for the design and use of oral vaccines, the
therapeutic use of oral tolerance and understanding of IBD. Previous studies using
activation of T cell receptor transgenic T cells to compare local and systemic distribution of …