Airway inflammation plays a major role in human asthma. Increasing evidence points to a
close correlation between eosinophil infiltration and allergic lung disease. A new murine
model of eosinophilic lung inflammation has recently been developed; it consists of
immunizing mice with small fragments of solidified hen egg white implanted (EWI) into the
subcutaneous tissue. In this model, which is further characterized here, mice challenged
with ovalbumin (OVA) present an intense and persistent lung eosinophilia, as well as …