[HTML][HTML] The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse
JW Chisholm, J Hong, SA Mills, RM Lawn - Journal of lipid research, 2003 - ASBMB
Liver X receptor (LXR) ligands are currently being evaluated as potential therapeutic agents
for the treatment of low HDL. The LXR ligand T0901317 elevates ATP binding cassette
transporter A1 (ABCA1) and HDL levels in animal models and induces moderate
lipogenesis through upregulation of sterol regulatory element binding protein 1c (SREBP1c).
Because insulin may also regulate lipogenesis through SREBP1c and fatty acid synthase
(FAS), we investigated the effect of an LXR ligand in hyperinsulinemic mice. Administration …
for the treatment of low HDL. The LXR ligand T0901317 elevates ATP binding cassette
transporter A1 (ABCA1) and HDL levels in animal models and induces moderate
lipogenesis through upregulation of sterol regulatory element binding protein 1c (SREBP1c).
Because insulin may also regulate lipogenesis through SREBP1c and fatty acid synthase
(FAS), we investigated the effect of an LXR ligand in hyperinsulinemic mice. Administration …