[HTML][HTML] Tumor necrosis factor-α activates NFκB to inhibit renin transcription by targeting cAMP-responsive element
VT Todorov, S Völkl, M Müller, A Bohla, J Klar… - Journal of Biological …, 2004 - ASBMB
Tumor necrosis factor-α (TNFα) is known to inhibit renin gene expression in juxtaglomerular
cells, which are the main source of renin in vivo. In the present study we aimed to
characterize the intracellular mechanisms of TNFα signaling to renin gene in the mouse
juxtaglomerular cell line As4. 1. TNFα was found to activate NFκB, which is one of the
principal intracellular mediators of TNFα signal transduction. Constitutive activation of NFκB
suppressed renin gene transcription, but NFκB appeared not to target the NFκB binding sites …
cells, which are the main source of renin in vivo. In the present study we aimed to
characterize the intracellular mechanisms of TNFα signaling to renin gene in the mouse
juxtaglomerular cell line As4. 1. TNFα was found to activate NFκB, which is one of the
principal intracellular mediators of TNFα signal transduction. Constitutive activation of NFκB
suppressed renin gene transcription, but NFκB appeared not to target the NFκB binding sites …