Epitope dominance, competition and T cell affinity maturation
RM Kedl, JW Kappler, P Marrack - Current opinion in immunology, 2003 - Elsevier
RM Kedl, JW Kappler, P Marrack
Current opinion in immunology, 2003•ElsevierCompetition for limited resources is a common theme throughout nature, and immunology is
no exception. Competition between T cells has been observed in one form or another for a
number of decades. Recent advances have allowed the detection of multiple populations of
T cells specific for either the same or disparate antigens during a response to a common
stimuli. The interplay of these populations of cells dictates both the quality and quantity of the
overall T cell response in the host.
no exception. Competition between T cells has been observed in one form or another for a
number of decades. Recent advances have allowed the detection of multiple populations of
T cells specific for either the same or disparate antigens during a response to a common
stimuli. The interplay of these populations of cells dictates both the quality and quantity of the
overall T cell response in the host.
Competition for limited resources is a common theme throughout nature, and immunology is no exception. Competition between T cells has been observed in one form or another for a number of decades. Recent advances have allowed the detection of multiple populations of T cells specific for either the same or disparate antigens during a response to a common stimuli. The interplay of these populations of cells dictates both the quality and quantity of the overall T cell response in the host.
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