Defective CD3-mediated cell death in activated T cells from patients with systemic lupus erythematosus: role of decreased intracellular TNF-α
B Kovacs, D Vassilopoulos, SA Vogelgesang… - Clinical immunology and …, 1996 - Elsevier
Activation-induced cell death (AICD) plays an important role in the regulation of the immune
response by eliminating preactivated and potentially autoreactive cells. To elucidate
possible abnormalities of AICD in human systemic lupus erythematosus (SLE), we studied
AICD in activated T cells from patients with SLE and normal controls. CD3-mediated cell
death was determined in short-term T cell lines by flow cytometry using propidium iodide
staining and analysis of DNA subdiploid peak populations. It was found to be significantly …
response by eliminating preactivated and potentially autoreactive cells. To elucidate
possible abnormalities of AICD in human systemic lupus erythematosus (SLE), we studied
AICD in activated T cells from patients with SLE and normal controls. CD3-mediated cell
death was determined in short-term T cell lines by flow cytometry using propidium iodide
staining and analysis of DNA subdiploid peak populations. It was found to be significantly …