Imbalanced cytokine production by macrophages from autoimmune-prone mice
J Levine, D Hartwell, DI Beller - Immunology letters, 1991 - Elsevier
Peritoneal macrophages from multiple autoimmune-prone strains of mice (MRL/lpr, MRL/+,
NZB/W, BXSB, and B6/gld) show defective expression of the cytokines IL-1 and IL-6.
Autoimmune mice were all used between 1 and 6 weeks of age, the earliest times being well
before the onset of overt disease. Northern blot analysis reveals a parallel reduction in the
levels of IL-1α, IL-1β, and IL-6 mRNA. In contrast, the production of other proteins, including
the cytokine TNF-α, appears to be normal. These findings imply an imbalance within the …
NZB/W, BXSB, and B6/gld) show defective expression of the cytokines IL-1 and IL-6.
Autoimmune mice were all used between 1 and 6 weeks of age, the earliest times being well
before the onset of overt disease. Northern blot analysis reveals a parallel reduction in the
levels of IL-1α, IL-1β, and IL-6 mRNA. In contrast, the production of other proteins, including
the cytokine TNF-α, appears to be normal. These findings imply an imbalance within the …