Immunologic and virologic effects of subcutaneous interleukin 2 in combination with antiretroviral therapy: a randomized controlled trial
RT Davey Jr, RL Murphy, FM Graziano, SL Boswell… - Jama, 2000 - jamanetwork.com
ContextWhile interleukin 2 (IL-2) is capable of inducing a marked expansion of the CD4 T-
lymphocyte pool, limited data exist on whether IL-2 treatment can add significantly to the
immunologic and virologic effects of potent antiretroviral therapy (ART). ObjectiveTo
determine the rate and magnitude of CD4 cell recovery and viral suppression when using a
combination therapy of IL-2 and ART compared with ART alone. Design and
SettingRandomized, controlled multicenter trial conducted from April 1996 through April …
lymphocyte pool, limited data exist on whether IL-2 treatment can add significantly to the
immunologic and virologic effects of potent antiretroviral therapy (ART). ObjectiveTo
determine the rate and magnitude of CD4 cell recovery and viral suppression when using a
combination therapy of IL-2 and ART compared with ART alone. Design and
SettingRandomized, controlled multicenter trial conducted from April 1996 through April …