The permeability transition (PT) pore, also called the mitochondrial megachannel or multiple
conductance channel, 1, 2, 3 is a dynamic multiprotein complex located at the contact site
between the inner and outer mitochondrial membranes, one of the critical sites of metabolic
coordination between the cytosol, the mitochondrial intermembrane space, and the matrix.
The PT pore participates in the regulation of matrix Ca 2+, pH, ΔΨ m (mitochondrial
transmembrane potential), and volume and functions as a Ca 2+-, voltage-, pH-, and redox …