Antiapoptotic mechanism of HIV protease inhibitors: preventing mitochondrial transmembrane potential loss
BN Phenix, JJ Lum, Z Nie… - Blood, The Journal …, 2001 - ashpublications.org
BN Phenix, JJ Lum, Z Nie, J Sanchez-Dardon, AD Badley
Blood, The Journal of the American Society of Hematology, 2001•ashpublications.orgTreatment of cells with the HIV drugs ritonavir, saquinavir, or nelfinavir (Nfv) inhibits
apoptosis induced by a variety of stimuli. Because these drugs are protease inhibitors, they
have been postulated to inhibit apoptosis by blocking caspase activity. This study shows that
Nfv has no effect on caspase activity or on the transcription or synthesis of a variety of
apoptosis regulatory molecules. Instead, Nfv inhibits mitochondrial transmembrane potential
loss (Δψm) and the subsequent release of apoptotic mediators. Consequently, the …
apoptosis induced by a variety of stimuli. Because these drugs are protease inhibitors, they
have been postulated to inhibit apoptosis by blocking caspase activity. This study shows that
Nfv has no effect on caspase activity or on the transcription or synthesis of a variety of
apoptosis regulatory molecules. Instead, Nfv inhibits mitochondrial transmembrane potential
loss (Δψm) and the subsequent release of apoptotic mediators. Consequently, the …
Treatment of cells with the HIV drugs ritonavir, saquinavir, or nelfinavir (Nfv) inhibits apoptosis induced by a variety of stimuli. Because these drugs are protease inhibitors, they have been postulated to inhibit apoptosis by blocking caspase activity. This study shows that Nfv has no effect on caspase activity or on the transcription or synthesis of a variety of apoptosis regulatory molecules. Instead, Nfv inhibits mitochondrial transmembrane potential loss (Δψm) and the subsequent release of apoptotic mediators. Consequently, the antiapoptotic effects of Nfv are restricted to apoptotic pathways that involve Δψm.
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