[HTML][HTML] Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase: differential regulation of Akt and MAP kinase pathways by EDG and bradykinin …
J Igarashi, SG Bernier, T Michel - Journal of Biological Chemistry, 2001 - ASBMB
Sphingosine 1-phosphate (S1P) is a platelet-derived sphingolipid that elicits numerous
biological responses in endothelial cells mediated by a family of G protein-coupled EDG
receptors. Stimulation of EDG receptors by S1P has been shown to activate the endothelial
isoform of nitric-oxide synthase (eNOS) in heterologous expression systems (Igarashi, J.,
and Michel, T.(2000) J. Biol. Chem. 275, 32363–32370). However, the signaling pathways
that modulate eNOS regulation by S1P/EDG in vascular endothelial cells remain less well …
biological responses in endothelial cells mediated by a family of G protein-coupled EDG
receptors. Stimulation of EDG receptors by S1P has been shown to activate the endothelial
isoform of nitric-oxide synthase (eNOS) in heterologous expression systems (Igarashi, J.,
and Michel, T.(2000) J. Biol. Chem. 275, 32363–32370). However, the signaling pathways
that modulate eNOS regulation by S1P/EDG in vascular endothelial cells remain less well …