Selection of successive tumour lines for metastasis
IJ Fidler - Nature New Biology, 1973 - nature.com
IJ Fidler
Nature New Biology, 1973•nature.comThe pathogenesis of metastasis begins with the invasion of tissues, blood vessels and/or
lymphatics by cells originating from a primary cancer. Following their release into the
circulation, most tumour emboli are initially arrested in the first capillary bed encountered,
but some recirculate and are trapped in other organs. After their initial arrest, tumour cells
must invade the parenchyma, establish a micro-environment, escape host defence
mechanisms and finally grow into secondary tumours1.
lymphatics by cells originating from a primary cancer. Following their release into the
circulation, most tumour emboli are initially arrested in the first capillary bed encountered,
but some recirculate and are trapped in other organs. After their initial arrest, tumour cells
must invade the parenchyma, establish a micro-environment, escape host defence
mechanisms and finally grow into secondary tumours1.
Abstract
The pathogenesis of metastasis begins with the invasion of tissues, blood vessels and/or lymphatics by cells originating from a primary cancer. Following their release into the circulation, most tumour emboli are initially arrested in the first capillary bed encountered, but some recirculate and are trapped in other organs. After their initial arrest, tumour cells must invade the parenchyma, establish a micro-environment, escape host defence mechanisms and finally grow into secondary tumours1.
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