[HTML][HTML] Functional requirement of the hypoxia-responsive element in the activation of the inducible nitric oxide synthase promoter by the iron chelator desferrioxamine
G Melillo, LS Taylor, A Brooks, T Musso, GW Cox… - Journal of Biological …, 1997 - ASBMB
We have previously reported that a 19-base pair element of the 5′-flanking region of the
inducible nitric oxide synthase (iNOS) gene containing a sequence homology to a hypoxia-
responsive enhancer (iNOS-HRE) mediates picolinic acid (PA)-or hypoxia-induced
activation of the iNOS promoter in interferon-γ (IFN-γ)-treated murine macrophages. The iron
chelator desferrioxamine (DFX) induces the activity of the human erythropoietin enhancer in
Hep3B cells. We have investigated the influence of DFX on the activation of the iNOS …
inducible nitric oxide synthase (iNOS) gene containing a sequence homology to a hypoxia-
responsive enhancer (iNOS-HRE) mediates picolinic acid (PA)-or hypoxia-induced
activation of the iNOS promoter in interferon-γ (IFN-γ)-treated murine macrophages. The iron
chelator desferrioxamine (DFX) induces the activity of the human erythropoietin enhancer in
Hep3B cells. We have investigated the influence of DFX on the activation of the iNOS …