ERM proteins and NF2 tumor suppressor: the Yin and Yang of cortical actin organization and cell growth signaling
A Gautreau, D Louvard, M Arpin - Current opinion in cell biology, 2002 - Elsevier
A Gautreau, D Louvard, M Arpin
Current opinion in cell biology, 2002•ElsevierThe ERM (ezrin, radixin and moesin) family of proteins are linkers that tether actin
microfilaments to the plasma membrane. Merlin, the NF2 tumor suppressor gene product, is
highly homologous to ERM proteins. In ERM proteins and merlin, interdomain binding
promotes auto-inhibition and homo-oligomerization or hetero-oligomerization. Recent
studies have revealed that ERM proteins transduce growth signals, and have shed new light
on how merlin links cell growth to the cytoskeleton.
microfilaments to the plasma membrane. Merlin, the NF2 tumor suppressor gene product, is
highly homologous to ERM proteins. In ERM proteins and merlin, interdomain binding
promotes auto-inhibition and homo-oligomerization or hetero-oligomerization. Recent
studies have revealed that ERM proteins transduce growth signals, and have shed new light
on how merlin links cell growth to the cytoskeleton.
The ERM (ezrin, radixin and moesin) family of proteins are linkers that tether actin microfilaments to the plasma membrane. Merlin, the NF2 tumor suppressor gene product, is highly homologous to ERM proteins. In ERM proteins and merlin, interdomain binding promotes auto-inhibition and homo-oligomerization or hetero-oligomerization. Recent studies have revealed that ERM proteins transduce growth signals, and have shed new light on how merlin links cell growth to the cytoskeleton.
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