[HTML][HTML] The PDZ domains of zonula occludens-1 induce an epithelial to mesenchymal transition of Madin-Darby canine kidney I cells: evidence for a role of β-catenin …
M Reichert, T Müller, W Hunziker - Journal of Biological Chemistry, 2000 - ASBMB
The integrity of cell-cell contacts such as adherens junctions (AJ) and tight junctions (TJ) is
essential for the function of epithelia. During carcinogenesis, the increased motility and
invasiveness of tumor cells reflect the loss of characteristic epithelial features, including cell
adhesion. While β-catenin, a component of AJ, plays a well characterized dual role in cell
adhesion and signal transduction leading to epithelial cell transformation, little is known
about possible roles of tight junction components in signaling processes. Here we show that …
essential for the function of epithelia. During carcinogenesis, the increased motility and
invasiveness of tumor cells reflect the loss of characteristic epithelial features, including cell
adhesion. While β-catenin, a component of AJ, plays a well characterized dual role in cell
adhesion and signal transduction leading to epithelial cell transformation, little is known
about possible roles of tight junction components in signaling processes. Here we show that …