Occludin expression decreases with the progression of human endometrial carcinoma

H Tobioka, H Isomura, Y Kokai, Y Tokunaga… - Human pathology, 2004 - Elsevier
The tight junctions of the glandular epithelium are crucial for the maintenance of cell polarity,
separating the plasma membrane into apical and basolateral domains. Thus abnormalities
of the tight junctions may result in the structural disturbances of glandular epithelial
neoplasia. In this study we introduced an anti-occludin monoclonal antibody for
semiquantitative assay of the occludin expression in tissue sections of human normal and
neoplastic endometrial epithelia using the Adobe Photoshop and NIH Image programs …