[HTML][HTML] Prevention of kidney ischemia/reperfusion-induced functional injury, MAPK and MAPK kinase activation, and inflammation by remote transient ureteral …
KM Park, C Kramers, M Vayssier-Taussat… - Journal of Biological …, 2002 - ASBMB
Protection against ischemic kidney injury is afforded by 24 h of ureteral obstruction (UO)
applied 6 or 8 days prior to the ischemia. Uremia or humoral factors are not responsible for
the protection, since unilateral UO confers protection on that kidney but not the contralateral
kidney. Prior UO results in reduced postischemic outer medullary congestion and leukocyte
infiltration. Prior UO results in reduced postischemic phosphorylation of c-Jun N-terminal
stress-activated protein kinase 1/2 (JNK1/2), p38, mitogen-activated protein kinase (MAPK) …
applied 6 or 8 days prior to the ischemia. Uremia or humoral factors are not responsible for
the protection, since unilateral UO confers protection on that kidney but not the contralateral
kidney. Prior UO results in reduced postischemic outer medullary congestion and leukocyte
infiltration. Prior UO results in reduced postischemic phosphorylation of c-Jun N-terminal
stress-activated protein kinase 1/2 (JNK1/2), p38, mitogen-activated protein kinase (MAPK) …