[HTML][HTML] Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions

H Peinado, M Quintanilla, A Cano - Journal of Biological Chemistry, 2003 - ASBMB
The Snail transcription factor has been described recently as a strong repressor of E-
cadherin in epithelial cell lines, where its stable expression leads to the loss of E-cadherin
expression and induces epithelial-mesenchymal transitions and an invasive phenotype. The
mechanisms regulating Snail expression in development and tumor progression are not yet
known. We show here that transforming growth factor β-1 (TGFβ1) induces Snail expression
in Madin-Darby canine kidney cells and triggers epithelial-mesenchymal transitions by a …